I bought these a few years ago and returned them a week later:
Klipsch ProMedia 2.1
Some people swear they're just the best, and while the subwoofer did have impressive bass (and clean), the satellites had weak mid-range. The self-proclaimed "audiophile" at best buy didn't know what he was talking about.
I looked these up on Amazon after seeing a lower model (AV30) in a store. Majority of reviews give the speakers very high marks and make note of tight punch and great midrange levels.
M-Audio Studiophile AV 40 ($136 on amazon, $150 on newegg)
From what I've read so far, the AV40's sound impressive to me and I might buy them. Maybe I can find a pair on display somewhere in town and listen to them for myself, as I've already found out the average listener doesn't know what good PC speakers can sound like.
Does anyone have any recommendations they'd like to share? I'll go ahead and note that I'm not using integrated audio on my motherboard either and my existing Boston Acoustics produce great clarity that I haven't heard matched yet by other PC speakers, but the audio jack is failing on the subwoofer so hence why I'm replacing them.

"Any sufficiently advanced technology is indistinguishable from magic" ~ Arthur C. Clarke