I am probably going to get stick for this, but nothing.
I have not optimized Windows 7 since i've had it and have had no problems with it, it's always ran quickly with no hiccups. If you want to squeeze that little bit of speed out of it you can do the usual tweaks of turning off the active previews, aero, gadgets, min/max animations and transparency.
Actually, turn transparency off anyway, because its bloody useless.
Obviously get your spunky new Dx11
drivers and i would recommend getting
Desktops from the official Microsoft
sysinternals website. It allows 4 virtual desktops and is probably the quickest one i've tried, the rest of the sysinternal software is also pretty good so take a browse around.
As for games, the first game i tried with Dx10 features was Bioshock, just seeing the small, but very noticeable water effect changes completely sold me. Far Cry 2 would be another good choice, then try something on a bigger scale, like supreme commander or another large scale RTS.
I'm not even going to mention trying crysis, because everyone else will probably say the same thing...
..wait, I just did.