I've not had any problems with ATI cards so far. The last Nvidia card I had however, just before Black & White 2 was released, was terrible. It kept acting weird, like loading textures onto models that weren't even supposed to be on them, like fences with cow textures on them and stuff, or loading the terrain as a completely red model, even after updating the drivers, which is the reason I originally switched to ATI.
PhysX to me, is just a gimmick. Nvidia charge more for cards with PhysX on them, which from what I've seen on a few friends PCs so far, has no performance gain what-so-ever, unless your using fluids. Most games don't make use of fluids, because not even Nividia's cards can handle enough of it to actually make it worth using (e.g. a river full of fluid water). Crazy Machines 2 so far, is the only except to that, which makes very little amounts of fluid very useful, which could be run by the CPU anyway.
Not to mention the hell you have to go through when trying to get hold of the "free" SDK to try on the pc. I still haven't been given access yet.
EDIT:
I do wish however, that TGC would finish Dark Physics or stop selling it. Its not worth £38.99 with half of the physX sdk features missing and broken or 'slapped-on' features like soft bodies, which felt like it was rushed in at last minute then forgotten about. Also vehicles.... I see a lot of posts in the PhysX board with problems about that part of the wrapper.