Mass Effect 3 - Definitely, ME and ME2 were both very good games and I loved them. I am a little disappointed that I finished ME on PC and not XBox 360 because 1) I had waaaaay too many troubles with the PC version and 2) I could only play ME2 on XBox (lack of compatible PC), so I couldn't use my old game save. However, ME3, I'm definitely getting it for the 360, I want to see what happens as a result of some of my actions, like (spoiler):
Royally annoying the Illusive Man
Making relations with Legion and Tali as well as influencing the Quarian Council to consider not starting war with the Geth on their home planet
When I finish my 'evil' playthrough, the effect of letting the baby Reaper live
The Elder Scrolls V: Morrowind and Oblivion were amazing, it'll be interesting to see how they top it.
Bioshock: Infinite: If it's being released, I don't know, but I'll look forward to it if it is.
Final Fantasy XIV - PS3 version: Because I don't have anything anywhere NEAR as powerful enough to run the PC version. I know it has got bad reviews, but it's an MMORPG and it was released early, but I have faith Sqaure will improve things and I suspect it'll have a game play I'll enjoy, it was the same for FFXI-Online and I LOVE that game.
Final Fantasy XI - Expansion: They're still updating the game with new content, from some of Square's comments, we're still to expect more expansions (2010 had the Abyssea expansion issued in 3 installments, the 3rd was just before Christmas, I suspect they might do something similar).
Dragon Age II: I enjoyed the first one, it's something I'll probably buy, but I wouldn't say I'm excited.
Crysis 2: It'll be interesting to play the console version as it'll probably be visually spectacular, as I've come to expect good things from Crytek in that department, also, I actually enjoyed Crysis and Crysis 2 looks interesting
Portal 2: I've enjoyed every vavle game I've played, including Portal, so why not Portal 2.
Abe's Oddysee HD?: I read that a game studio is remaking Abe's Oddyssee with a 3D physics engine and are claiming they'll retain the original game's feel. If it's a 2011 release, then, well, I'll definitely grab it.

I love the Abe games! They're the only games to had frustrated me enough (in a good way) for me to genuinely swear at the computer screen. I've never managed to save ALL the mudokons without cheating. I'm playing through Munch's Odyssee now (never had an original XBox, so I never played it) and I am kind of disappointed, because it feels like a standard 3D platformer to me, like Rayman 2 in someways (Rayman 2 was great, but it's not what you'd expect an Oddworld game to be like)