It really depends on how big your game is, because along with polygon limitations, you have to consider scale limitations due to floating point accuracy too.
I would suggest that if it's a terrain based game, use 1 DBPro unit to represent 1 metre - so each tile on your terrain is 1 metre, or therabouts. If your game is set inside, maybe extend that so 1 DBPro unit represents 1 foot.
Once you decide that, modelling to scale is a lot easier - if you know that 7x4 units is a good sized door, or 5 units is a good width for a corridor.
Even once you have a strict scale in place, it's still a good idea to make a manekin - like a basic 3D character model, that you use as a guide for modelling - especially usefull for vehicle modelling too.

Health, Ammo, and bacon and eggs!
