Not sure if this is something most of you think "Duh!" or not, but here's what could be lurking inside your case. I've had a usb card reader for awhile now and finally decided to actually put it in the case and hook it up to the internal usb. I figured since I have the case open I may as well clean it.
I built this system late summer of 2007 and it's pretty much been running 24/7 since. Antec P180 case is nice and quiet, good air flow, and has filters on the front vents. Didn't think it'd get so dusty inside. So here's what more than 3 years of dust looks like. This is a stock intel heatsink for a C2D with the fan removed:
Cleaned out the case and fans, removed the graphics card and clean the heatsink/fan on it, and pulled off the CPU heatsink and also removed it's fan. (also applied fresh thermal paste, ceramic I think) Computer runs a few degrees cooler now, CPU around 35-39, overall system registers at 31-34.
As a side note, I found it interesting that my BIOS records how long the computer has been turned on.
PC Uptime Total: 29,349 hours
Power Cycles: 168
Reset Cycles: 44
AC Power On Total: 31,946 hours
AC Power Cycles: 45
That's 1222 days, or 3.34 years. So when I said it's been running since I built it, I wasn't exaggerating!