Oh, forget ponies.
I have a GREAT idea! How about a game like Dungeon Keeper? We have so few of this kind!
Story: you are the Super Villain that live on the Moon and want to take control over the Earth.
Gameplay: you are building a moon base.
Goal: to build a super weapon.
Ways to do it: there should be several super weapons, like Nuclear Rocket, Giant Laser or Brainwashing Ray.
or exploding ponies
Disasters: like meteor storm or rockets from Earth (military): ruin your base and damaging Super Weapons.
Economics: some mafia people arrive from earth in shuttles with money or resourses in exchange for missions or secrets plans or whatever. You have to buy some details on Earth (you can't have everything on the Moon!). Also you mine iron, uran and stones on the Moon.
Enemies: military shuttles with troops and Super Heroes like James Bond.