Take away the mouse, and just have the pad that responds to your hand movements, and to click the buttons you just tap the pad with your finger, two fingers for the right mouse button, slide your finger for the wheel.. etc. Try it on your mouse pad... it feels very comfortable.
To make this work you would just check for the distance from your hands fat palm area, to a finger, and the second finger would make two circular responses. Sliding the finger would create a zone that moves in a linear direction. Basically you are checking distances, and last position, new position.