Sizes which not the powers of 2 will result in distorted texture both in sprites and 3D. This is due to the way the graphics cards work with the images, and the way how DBP handles sprites as 'locked onto the screen' 3D plains.
So nope, this won't be easier to handle, in fact it is very uncomfortable to work with if your media does not fit into a nice box.
However as i recently discovered, you can work around this by creating an animated sprite! If the sprite is not animated, you just give it flags saying it is one frame both horizontally and vertically, and there you can have a custom sized / resolution sprite.
Also be aware of that there is a paste sprite command, which disables the need of separate sprites for every little aspects of your game. For example if you want to write text using a custom bitmap font, you only need one animated sprite loaded with the bmp containing the predrawn letters, you set the sprite's frame each time, and paste it in the next letter's position.
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