For mysql, check out mysql workbench
For mssql, check out sql server management studio
Both are free management interfaces, though sql server the actual db engine for mssql can be pricey for the full version, it also has a free express/ community edition.
C# has native interfaces for sql server that you can use to run raw queries, but it also has the Entity Framework which will map the database directly to class objects with two way binding (meaning you can CRUD the db just by working with variables like any other data in the application without dealing with raw sql)
C# also has libraries for connecting to mysql, run a search in the nuget package manager
As far as integrating with tier 1, you'd probably want to just make a web request to the server which is hosting the db, and the web server can perform the db work then send back the results as a response
For a web host / API interface, Asp.net integrates closely with SQL server and php integrates easily with mysql.
There is also sqlite for small db running off the local file system or fully embedded into an application. Duffer made an excellent sqlite plugin for dbpro, but I don't think anything is currently available for agk tier1 for this
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