UNIX commands ok, find the windows variants if you have to.
find the ip of the mail server with an nslookup
type nslookup
then type the domain name
then type set type=ANY
then feed in the domain
look for the mail ip address.
do a stealth port scan on that machine using nmap.
if you see a plethora of open ports theres a good chance its infected.
if you see a port like 65301/tcp open pcanywhere its a good chance that machines been compromised. port 25 as you prolly know is usually the mail server.
or
whois the domain and speak to the admin or the person who set up the server.
9 times out of ten they will be glad to work with you to block a few ports and stop nonsense attacks.
A lot of information can be found in the mail headers, have a squizz at the ones you dont like.
If no-one gives your an answer to a question you have asked, consider:- Is your question clear.- Did you ask nicely.- Are you showing any effort to solve the problem yourself 