I am a web developer too, and though Chrome is GREAT at handling JavaScript, it has yet to handle more advanced things to the full potential such as a combination of AJAX and JavaScript. I think honestly the most developed in the JavaScript area would have to be Firefox, and for rendering Opera (a little too picky sometimes). As for Internet Explorer...let's not go there.
I notice when using Chrome for JavaScript intense sites, it tends to bug out or go slower.
Of course, I only use Chrome now for Google Wave (I was one of the first ones to be part of the developer preview, no lies, I have proof if needed.). It works well with that (naturally).
Temporarly away from the Phoenix Sentry.